Article
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.
Visual neuroscience - 1 Jan 2000
Pinto Lawrence H, Vitaterna Martha H, Shimomura Kazuhiro, Siepka Sandra M, Balannik Victoria, McDearmon Erin L, Omura Chiaki, Lumayag Stephen, Invergo Brandon M, Glawe Brett, Cantrell Donald R, Inayat Samsoon, Olvera Marissa A, Vessey Kirstan A, McCall Maureen A, Maddox Dennis, Morgans Catherine W, Young Brandon, Pletcher Mathew T, Mullins Robert F, Troy John B, Takahashi Joseph S
Abstract excerpt
We performed genome-wide chemical mutagenesis of C57BL/6J mice using N-ethyl-N-nitrosourea (ENU). Electroretinographic screening of the third generation offspring revealed two G3 individuals from one G1 family with a normal a-wave but lacking the b-wave that we named nob4. The mutation was transmitted with a recessive mode of inheritance and mapped to chromosome 11 in a region containing the Grm6 gene, which...
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