Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells.

The Journal of biological chemistry - 1 Dec 2021

Agosto Melina A, Adeosun Abiodun Adefola R, Kumar Nitin, Wensel Theodore G

Abstract excerpt

Signals from retinal photoreceptors are processed in two parallel channels-the ON channel responds to light increments, while the OFF channel responds to light decrements. The ON pathway is mediated by ON type bipolar cells (BCs), which receive glutamatergic synaptic input from photoreceptors via a G-protein-coupled receptor signaling cascade. The metabotropic glutamate receptor mGluR6 is located at the dendritic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Photoreceptor Cells, Vertebrate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Domains

Share to Protein Transport

Share to Receptors, Metabotropic Glutamate

Share to Synapses

Share to Synaptic Transmission

Share to TRPM Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 34793838
DOI: 10.1016/j.jbc.2021.101418
PMCID: PMC8671642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells.PMID 34793838Read ↗

Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutantsSemantic proximity Read ↗

Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants.Semantic proximity Read ↗

mGluR6 coordinates cone terminal targeting and synaptic layer assembly during human retinal developmentSemantic proximity Read ↗

LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.Semantic proximity Read ↗

Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6.Semantic proximity Read ↗

Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6.Semantic proximity Read ↗

Restoration of mGluR6 Localization Following AAV-Mediated Delivery in a Mouse Model of Congenital Stationary Night BlindnessSemantic proximity Read ↗

Reduced expression of the nob8 gene does not normalize the distribution or function of mGluR6 in the mouse retina.Semantic proximity Read ↗

Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness.Semantic proximity Read ↗

TRPM1.Semantic proximity Read ↗

CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Semantic proximity Read ↗

Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.