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SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine Learning

2023-06-27

Abstract excerpt

Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for TWAS. To leverage expression imputation models (i.e., base models) trained with multiple reference panels, regression methods, and tissues, we develop a Stacked Regression based TWAS (SR-TWAS) tool which can obtain optimal linear combinations...

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Literature Corpus work
a16cd358-bda5-5b88-8749-6bf575f27195
DOI
10.1101/2023.06.20.23291605
Open publication

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SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine LearningDOI 10.1101/2023.06.20.23291605
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