Article

A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer’s Disease and Related Dementias (ADRD)

2024-07-23

Abstract excerpt

<h4>Summary</h4> We developed an imputation panel for Alzheimer’s disease (AD) and related dementias (ADRD) using whole-genome sequencing (WGS) data from the Alzheimer’s Disease Sequencing Project (ADSP). Recognizing the significant associations between structural variants (SVs) and AD, and their underrepresentation in existing public reference panels, our panel uniquely integrates single nucleotide variants (SNVs...

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Literature Corpus work: 4eb59cdd-45a8-5e33-8af6-ded204afe042
DOI: 10.1101/2024.07.22.24310827

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