Article
SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning.
Nature communications - 5 Aug 2024
Parrish Randy L, Buchman Aron S, Tasaki Shinya, Wang Yanling, Avey Denis, Xu Jishu, De Jager Philip L, Bennett David A, Epstein Michael P, Yang Jingjing
Abstract excerpt
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expression imputation models (i.e., base models) trained with multiple reference panels, regression methods, and tissues, we develop a Stacked Regression based TWAS (SR-TWAS) tool...
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