Article

Meta-imputation of transcriptome from genotypes across multiple datasets using summary-level data

2021-05-04

Abstract excerpt

Transcriptome wide association studies (TWAS) can be used as a powerful method to identify and interpret the underlying biological mechanisms behind GWAS by mapping gene expression levels with phenotypes. In TWAS, gene expression is often imputed from individual-level genotypes of regulatory variants identified from external resources, such as Genotype-Tissue Expression (GTEx) Project. In this setting, a straightf...

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Literature Corpus work: 82a07ab0-f24f-50b2-bee4-68bab36887ad
DOI: 10.1101/2021.05.04.442575

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