Article

GBoost-CTL: A novel method in multi-tissue transcriptome-wide associations studies in cross-tissue learner incorporating GWAS information

2025-11-22

Abstract excerpt

Genome-wide association studies (GWAS) have uncovered numerous genetic variants linked to complex human diseases, yet linking these variants to transcripts and tissues that drive pathology remains difficult. Multi-tissue transcriptome-wide association studies (TWAS) offer a powerful bridge, but existing analytical methods have some limitations, either by discarding important signals by separately analyzing and the...

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Literature Corpus work: 66d1c481-e125-53a6-b929-5bfdc4c2255f
DOI: 10.1101/2025.11.22.689782

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