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Article

Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells

13 Mar 2015

Abstract excerpt

It is not well understood how paracrine communication between basal and luminal cell populations in the mammary gland affects tumorigenesis. During ErbB2-induced mammary tumorigenesis, enriched mammary stem cells that represent a subpopulation of basal cells exhibit enhanced tumorigenic capacity compared with the corresponding luminal progenitors. Transcript profiling of tumors derived from basal and luminal...

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PMID: 25769722
DOI: 10.1158/0008-5472.can-14-2761

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