Article

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer

2023-04-28

Abstract excerpt

Basal-like breast cancer is an aggressive breast cancer subtype, often characterized by a deficiency in BRCA1 function and concomitant loss of p53 . While conventional mouse models enable the investigation of its malignant stages, one that reveals its initiation and pre-malignant progression is lacking. Here, we leveraged a mouse genetic system known as M osaic A nalysis with D ouble M arkers (MADM) to gener...

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Literature Corpus work: 0a6807be-077b-5ea7-b203-34df0780a398
DOI: 10.1101/2023.04.25.538333

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