Article

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

2021-10-26

Abstract excerpt

<h4>Summary</h4> Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 222 human proteins localized to BMs. Network analysis and screening in C. elegans and zebrafish identified new BM regulators, including ADAMTS, ROBO, and TG...

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Literature Corpus work: 2ac25984-19cf-5db2-a5ae-5560ceeb01ad
DOI: 10.1101/2021.10.25.465762

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