Article

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents

2025-01-09

Abstract excerpt

<h4>ABSTRACT</h4> DNA-damaging agents (DDAs) have long been used in cancer therapy. However, the precise mechanisms by which DDAs induce cell death are not fully understood and drug resistance remains a major clinical challenge. Schlafen 11 (SLFN11) was identified as the gene most strongly correlated with the sensitivity to DDAs based on mRNA expression levels. SLFN11 sensitizes cancer cells to DDAs by cleaving a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4a6a8d4-09de-502e-a6ab-a8d198a078ca
DOI: 10.1101/2025.01.08.632070

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agentsDOI 10.1101/2025.01.08.632070Read

SLFN11 is a general target for enhancing the sensitivity of cancer to chemotherapy (DNA-damaging agents)Semantic proximity Read

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243Semantic proximity Read

SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosisSemantic proximity Read

SLFN11: a pan-cancer biomarker for DNA-targeted drugs sensitivity and therapeutic strategy guidanceSemantic proximity Read

tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human diseaseSemantic proximity Read

The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13Semantic proximity Read

Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutationsSemantic proximity Read

The Roles of tRNA-Derived Fragments in Cancers: Updates and PerspectivesSemantic proximity Read

Structural, molecular, and functional insights into Schlafen proteinsSemantic proximity Read

Targeting the hallmarks of cancer with therapy-induced endoplasmic reticulum (ER) stressSemantic proximity Read

Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agentsSemantic proximity Read

RNA-seq Analysis Reveals Upregulation in ER -Stress-Related Genes Upon LCL-161 Treatment in SH-SY5Y Human Neuroblastoma CellsSemantic proximity Read