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Article

Therapeutic targets for atherosclerotic coronary artery disease: druggable genome-wide Mendelian randomization analysis.

Atherosclerosis - 1 Aug 2026

Wang Wenbin, Sun Yingxian, Chang Kejia, Zheng Zhenzhong

Abstract excerpt

BACKGROUND AND AIMS: Despite advances in treating atherosclerotic coronary artery disease (ACAD), the risk of major adverse cardiovascular events remains high. We aimed to identify potential therapeutic targets for ACAD by integrating genome-wide association studies (GWAS) and Mendelian randomization (MR) analyses. METHODS: Leveraging druggable genome data, cis-eQTL/cis-pQTL from blood and coronary artery tissue,...

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Identifiers

PMID: 42308999
DOI: 10.1016/j.atherosclerosis.2026.120810

Genes

TGFA
CES2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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