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Article

Uncovering Potential Druggable Targets in Coronary Atherosclerosis: A Proteome-Wide Mendelian Randomization Study With Cross-Platform and Experimental Validation.

Cardiovascular therapeutics - 1 Jan 2026

Gao Da, Lin Haiyan, Wang Shengjie, Wang Yanwei, Yang Hao, Wang Zicheng

Abstract excerpt

BACKGROUND: Coronary atherosclerosis (CA) is a leading cause of cardiovascular morbidity and mortality worldwide. This study is aimed at identifying candidate plasma proteins and potential therapeutic targets for CA. METHODS: We performed a proteome-wide Mendelian randomization (MR) analysis using integrated protein quantitative trait loci (pQTLs) and genome-wide association study (GWAS) summary data. Forward...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42666106
DOI: 10.1155/cdr/7359278
PMCID: PMC13525442

Genes

PARP1
FOLH1
FST
NCAN
SDCCAG8

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