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Mutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism.

Clinical and translational medicine - 1 Jan 2024

Xie Fanfan, Guo Wenjie, Wang Xingguo, Zhou Kaixiang, Guo Shanshan, Liu Yang, Sun Tianlei, Li Shengjing, Xu Zhiyang, Yuan Qing, Zhang Huanqin, Gu Xiwen, Xing Jinliang, Liu Shujuan

Abstract excerpt

BACKGROUND: Epithelial ovarian cancer (EOC) heavily relies on oxidative phosphorylation (OXPHOS) and exhibits distinct mitochondrial metabolic reprogramming. Up to now, the evolutionary pattern of somatic mitochondrial DNA (mtDNA) mutations in EOC tissues and their potential roles in metabolic remodelling have not been systematically elucidated. METHODS: Based on a large somatic mtDNA mutation dataset from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38193640
DOI: 10.1002/ctm2.1523
PMCID: PMC10775184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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