Article
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA.
Nature metabolism - 1 Apr 2021
Gorelick Alexander N, Kim Minsoo, Chatila Walid K, La Konnor, Hakimi A Ari, Berger Michael F, Taylor Barry S, Gammage Payam A, Reznik Ed
Abstract excerpt
Mitochondrial DNA (mtDNA) encodes protein subunits and translational machinery required for oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data, in the present study we demonstrate that pathogenic mtDNA mutations arise in tumours at a rate comparable to those in the most common cancer driver genes. We identify OXPHOS complexes as critical determinants shaping somatic mtDNA mutation...
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