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Spectrum of somatic mitochondrial mutations in five cancers

13 Aug 2012

Abstract excerpt

Somatic mtDNA mutations have been reported in some human tumors, but their spectrum in different malignancies and their role in cancer development remain incompletely understood. Here, we describe the breadth of somatic and inherited mutations across the mitochondrial genome by sequence analyses of paired tumor and normal tissue samples from 226 individuals with five types of cancer using whole-genome data...

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PMID: 22891333
DOI: 10.1073/pnas.1211502109

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