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Article

Peptide-driven identification of TCRs reveals dynamics and phenotypes of CD4 T cells in tuberculosis.

Journal of immunology (Baltimore, Md. : 1950) - 9 Feb 2026

Tippalagama Rashmi, Trevizani Raphael, Chihab Leila Y, Chawla Ashu, Fung Kai, Greenbaum Jason, Kearns Kendall, De Silva Aruna D, Gunasinghe Wathsala, Perera Judy, Gunasekara Hansani, Senevirathne Darsha D, Scriba Thomas, Sette Alessandro, Lindestam Arlehamn Cecilia, Burel Julie G, Peters Bjoern

Abstract excerpt

Assigning antigen specificity to T cell receptor (TCR) sequences is challenging due to the TCR repertoire's diversity and the complexity of TCR-antigen recognition. We developed the peptide-driven identification of TCRs (PDI-TCR) assay that combines in vitro expansion of cells with peptide pools, bulk TCR sequencing, and statistical analysis to identify antigen-specific TCRs from human blood. A key feature of...

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Share to Antigens, Bacterial
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Mycobacterium tuberculosis

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 41241821
DOI: 10.1093/jimmun/vkaf287
PMCID: PMC12718515

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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