Article

Recovery of Paired T Cell Receptors from Single-cell Seq-Well Libraries

2023-08-23

Abstract excerpt

<title>Abstract</title> <p> High-throughput 3’ single-cell RNA-Sequencing (scRNA-Seq) allows for cost-effective, detailed characterization of thousands of individual immune cells from healthy and diseased tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including the variable sequences of T cell receptors (TCRs) that confer antigen specificity in T c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23ff75d5-fbb7-5fdc-9a46-f305410d20e8
DOI: 10.21203/rs.2.13685/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recovery of Paired T Cell Receptors from Single-cell Seq-Well LibrariesDOI 10.21203/rs.2.13685/v2Read

Discovery of rare antigen-specific TCRs via replicate profilingSemantic proximity Read

FB5P-seq: FACS-based 5-prime end single-cell RNAseq for integrative analysis of transcriptome and antigen receptor repertoire in B and T cellsSemantic proximity Read

Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation stateSemantic proximity Read

<i>CROCKETA:</i> An automated framework for comprehensive multi-omic analysis of gene expression and clonotype immune repertoire at a single-cell levelSemantic proximity Read

Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer ImmunotherapySemantic proximity Read

TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencingSemantic proximity Read

Rigorous benchmarking of T-cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read

High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8 <sup>+</sup> T cellsSemantic proximity Read

Rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read

High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells.Semantic proximity Read

Comparative benchmarking of single-cell transcriptomes and immune repertoires across technologiesSemantic proximity Read

A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T CellsSemantic proximity Read