Article

Inhibition of TGFβ-induced Fibroblast to Myofibroblast Transition by Conditioned Medium From Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2

2022-02-04

Abstract excerpt

<h4>Background: </h4> Airway remodeling, including increased deposition of extracellular matrix proteins, is a hallmark of asthma. Myofibroblasts, derived via fibroblast to myofibroblast transition (FMT), play an important role in this increased deposition of matrix proteins. Expression of transforming growth factor β1 (TGFβ1) is increased in asthmatic airways and is known to induce FMT, as assessed by increased e...

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Literature Corpus work: a1061761-51c1-53d7-bc35-3dc2eb712408
DOI: 10.21203/rs.3.rs-1296940/v1

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