Article
Rev-erbα agonists suppresses TGFβ1-induced fibroblast-to-myofibroblast transition and pro-fibrotic phenotype in human lung fibroblasts.
Biochemical and biophysical research communications - 20 Aug 2023
Prasad Chandrashekhar, Hahn Kameron, Duraisamy Santosh Kumar, Salathe Matthias A, Huang Steven K, Burris Thomas P, Sundar Isaac Kirubakaran
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by excessive scarring of the lungs that can lead to respiratory failure and death. Lungs of patients with IPF demonstrate excessive deposition of extracellular matrix (ECM) and an increased presence of pro-fibrotic mediators such as transforming growth factor-beta 1 (TGFβ1), which is a major driver of fibroblast-to-myofibroblast...
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