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Article

Enhanced upregulation of smooth muscle related transcripts by TGF 2 in asthmatic (myo) fibroblasts

1 Feb 2006

Abstract excerpt

BACKGROUND: Transforming growth factor beta (TGF beta) upregulates a number of smooth muscle specific genes in (myo)fibroblasts. As asthma is characterised by an increase in airway smooth muscle, we postulated that TGFbeta(2) favours differentiation of asthmatic (myo)fibroblasts towards a smooth muscle phenotype. METHODS: Primary fibroblasts were grown from bronchial biopsy specimens from normal (n = 6) and...

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Identifiers

PMID: 16449267
DOI: 10.1136/thx.2005.050005

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