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M1 Macrophage-Derived Exosomal miR-155-5p Exacerbates Aortic Dissection Progression via SMAD5-Mediated Regulation of Vascular Smooth Muscle Cell Phenotype

2026-03-05

Abstract excerpt

<title>Abstract</title> <p>Background Aortic dissection (AD) constitutes a critical and potentially lethal cardiovascular emergency, yet its underlying pathogenesis remains largely obscure. The present research aimed to elucidate the contribution of exosomes derived from M1 macrophages—particularly those carrying a high load of miR-155-5p—to the exacerbation of AD. Methods Macrophage infiltration and exosome di...

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Literature Corpus work
a100a9b9-ea70-55ea-aff7-76f9c447033d
DOI
10.21203/rs.3.rs-8986811/v1
Open publication

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M1 Macrophage-Derived Exosomal miR-155-5p Exacerbates Aortic Dissection Progression via SMAD5-Mediated Regulation of Vascular Smooth Muscle Cell PhenotypeDOI 10.21203/rs.3.rs-8986811/v1
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