Article

Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data)

2018-08-09

Abstract excerpt

<h4>ABSTRACT</h4> The genetic architecture of complex human traits and diseases is affected by large number of possibly interacting genes, but detecting epistatic interactions can be challenging. In the last decade, several studies have alluded to problems that linkage disequilibrium can create when testing for epistatic interactions between DNA markers. However, these problems have not been formalized nor have t...

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Literature Corpus work: a0e173ba-70c2-51fc-9705-7191369fa2ed
DOI: 10.1101/388942

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