Phantom epistasis through the lens of genealogies.

Abstract excerpt

Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive effect on the phenotype causes the spurious inference of a significant interaction between two single-nucleotide polymorphisms (SNPs). This is more likely to arise when the two SNPs are in relatively close proximity, so while true epistasis between nearby variants could be...

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