Disease model distortion in association studies.

Abstract excerpt

Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a single nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects. As others have noted, departures from this multiplicative model are difficult to detect. Here, we seek to quantify this both...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Case-Control Studies
• Share to Computer Simulation