Article
High-resolution comparative analysis of great ape genomes.
Science (New York, N.Y.) - 8 Jun 2018
Kronenberg Zev N, Fiddes Ian T, Gordon David, Murali Shwetha, Cantsilieris Stuart, Meyerson Olivia S, Underwood Jason G, Nelson Bradley J, Chaisson Mark J P, Dougherty Max L, Munson Katherine M, Hastie Alex R, Diekhans Mark, Hormozdiari Fereydoun, Lorusso Nicola, Hoekzema Kendra, Qiu Ruolan, Clark Karen, Raja Archana, Welch AnneMarie E, Sorensen Melanie, Baker Carl, Fulton Robert S, Armstrong Joel, Graves-Lindsay Tina A, Denli Ahmet M, Hoppe Emma R, Hsieh PingHsun, Hill Christopher M, Pang Andy Wing Chun, Lee Joyce, Lam Ernest T, Dutcher Susan K, Gage Fred H, Warren Wesley C, Shendure Jay, Haussler David, Schneider Valerie A, Cao Han, Ventura Mario, Wilson Richard K, Paten Benedict, Pollen Alex, Eichler Evan E
Abstract excerpt
Genetic studies of human evolution require high-quality contiguous ape genome assemblies that are not guided by the human reference. We coupled long-read sequence assembly and full-length complementary DNA sequencing with a multiplatform scaffolding approach to produce ab initio chimpanzee and orangutan genome assemblies. By comparing these with two long-read de novo human genome assemblies and a gorilla genome...
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