Article

Accounting for <i>cis</i> -regulatory constraint prioritizes genes likely to affect species-specific traits

2022-03-30

Abstract excerpt

Measuring allele-specific expression in interspecies hybrids is a powerful way to detect cis-regulatory changes underlying adaptation. However, it remains difficult to identify genes most likely to explain species-specific traits. Here, we outline a simple strategy that leverages population-scale allele-specific RNA-seq data to identify genes that have constrained cis - regulation within species yet show divergen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a470765-7e11-50b8-a049-387635b15a6a
DOI: 10.1101/2022.03.29.486301

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Accounting for <i>cis</i> -regulatory constraint prioritizes genes likely to affect species-specific traitsDOI 10.1101/2022.03.29.486301Read

Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits.Semantic proximity Read

Cell type-specific <i>cis</i> -regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cellsSemantic proximity Read

Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulationSemantic proximity Read

Co-regulatory changes in <i>Homo sapiens</i> prefrontal cortex shape RNA-chromatin interactionsSemantic proximity Read

Evolution of regulatory signatures in primate cortical neurons at cell type resolutionSemantic proximity Read

Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolutionSemantic proximity Read

<i>Cis</i> -regulation and natural selection in the evolution of human DNA methylationSemantic proximity Read

Single-cell genomic atlas of great ape cerebral organoids uncovers human-specific features of brain developmentSemantic proximity Read

Embryoid bodies facilitate comparative analysis of gene expression in humans and chimpanzees across dozens of cell typesSemantic proximity Read

Brain region-specific effects of nearly fixed sapiens-derived alleles.Semantic proximity Read

Modern human alleles differentially regulate gene expression across brain regions: implications for brain evolutionSemantic proximity Read

Fixed human pangenome sequences reveal origins of common human traitsSemantic proximity Read