Article

Masitinib is an oral, brain penetrant inhibitor of microglial and mast cell activity with neuroprotective potential in progressive forms of multiple sclerosis

2026-07-07

Abstract excerpt

<h4>Introduction</h4> Progressive multiple sclerosis (MS), including primary progressive MS (PPMS) and non-active secondary progressive MS (nSPMS), remains an unmet need, as few treatments target innate immune pathways. Masitinib (AB1010) is a selective tyrosine kinase inhibitor that targets c-Kit and colony-stimulating factor 1 receptor pathways. This mechanism disrupts mast cell-microglia interactions, key inna...

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Literature Corpus work: a0b0ca6b-de30-55c8-8e63-919e2c76eac8
DOI: 10.64898/2026.07.02.735783

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