Article

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

2023-08-29

Abstract excerpt

In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining the balance between myelin repair and demyelination/neurodegeneration. Phagocytic and regenerative functions of these CNS innate immune cells support remyelination, whereas chronic and maladaptive inflammatory activation promotes lesion expansion and disability, particularly in the pr...

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Literature Corpus work: 6b760030-0abf-5f4e-b57c-b020dbc4c8c7
DOI: 10.1101/2023.08.28.555084

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