Article

Plasmalogen-Independent Neuroprotection: Synthetic alkyl ether lipids activate signaling to mitigate neuroinflammation and enhance cognitive function

2025-12-11

Abstract excerpt

Neuroinflammation is a key driver of neurodegenerative disorders, with chronic activation of the NF-κB pathway contributing to neuronal dysfunction and disease progression. In this study, we report that KIT-8, a synthetic alkyl ether lipid, exerts potent anti-inflammatory and neuroprotective effects despite its inability to be converted into plasmalogens within cells unlike its analog KIT-13, which is known to gen...

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Literature Corpus work: 4156e86c-6081-5b75-bfbf-56b37ab6bff2
DOI: 10.64898/2025.12.08.693101

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