Article

Dynamics of spinal fluid immune cell alterations following cladribine tablet treatment in multiple sclerosis

2025-02-27

Abstract excerpt

<h4>Background and Objectives</h4> Oral cladribine tablet (CladT) therapy is efficacious for relapsing multiple sclerosis (MS). However, the mechanisms by which cladribine exerts benefit in MS remain unclear, particularly regarding its effects on compartmentalized inflammation within the cerebrospinal fluid (CSF). <h4>Methods</h4> Transcriptional profiles along with T and B lymphocyte receptor repertoires from CSF...

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Literature Corpus work: b3c9685e-dfab-5b84-bb69-ec4638cd488f
DOI: 10.1101/2025.02.22.25322629

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