Article

CSF1R inhibitors pexidartinib and sotuletinib induce rapid glial ablation despite their limited brain penetrability

2025-10-13

Abstract excerpt

<h4>Background</h4> Microglial reactivity, a hallmark of many neurodegenerative diseases, is thought to contribute significantly to disease pathology. In experimental models, colony stimulating factor 1 receptor (CSF1R) inhibitors transiently deplete microglia to resolve inflammation, leading to improved neuropathology. In oncology, CSF1R inhibitors modulate tumor-associated macrophages (TAMs) toward a tumor-supp...

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Literature Corpus work: 7407716d-3f10-572a-a53e-ed10fd5b6ef8
DOI: 10.1101/2025.10.11.681780

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