Article

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

2023-05-11

Abstract excerpt

African trypanosomes evade host immune clearance by antigenic variation, causing persistent infections in humans and animals. These parasites express a homogeneous surface coat of variant surface glycoproteins (VSGs). They transcribe one out of hundreds of VSG genes at a time from telomeric expression sites (ESs) and periodically change the VSG expressed by transcriptional switching or recombination. The mechanism...

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Literature Corpus work: a0a06807-f827-5631-a549-bf90e7e24d3f
DOI: 10.1101/2023.05.11.540368

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