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Article

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.

eLife - 20 May 2014

Batram Christopher, Jones Nicola G, Janzen Christian J, Markert Sebastian M, Engstler Markus

Abstract excerpt

We have discovered a new mechanism of monoallelic gene expression that links antigenic variation, cell cycle, and development in the model parasite Trypanosoma brucei. African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but only one is expressed from a telomeric expression site (ES) at any given time. We found that the expression of a second VSG alone is sufficient to silence the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24844706
DOI: 10.7554/eLife.02324
PMCID: PMC4027811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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