Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?

Gene - 1 Feb 2015

Günzl Arthur, Kirkham Justin K, Nguyen Tu N, Badjatia Nitika, Park Sung Hee

Abstract excerpt

Trypanosoma brucei is a vector borne, lethal protistan parasite of humans and livestock in sub-Saharan Africa. Antigenic variation of its cell surface coat enables the parasite to evade adaptive immune responses and to live freely in the blood of its mammalian hosts. The coat consists of ten million copies of variant surface glycoprotein (VSG) that is expressed from a single VSG gene, drawn from a large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Protozoan

Share to RNA Polymerase I

Share to Telomere

Share to Transcription Initiation Site

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 25261847
DOI: 10.1016/j.gene.2014.09.047
PMCID: PMC4272636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?PMID 25261847Read ↗

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.Semantic proximity Read ↗

Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma bruceiSemantic proximity Read ↗

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma bruceiSemantic proximity Read ↗

TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Semantic proximity Read ↗

A novel ISWI is involved in VSG expression site downregulation in African trypanosomes.Semantic proximity Read ↗

Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.Semantic proximity Read ↗

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.Semantic proximity Read ↗

Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.Semantic proximity Read ↗

Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activatorSemantic proximity Read ↗

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomesSemantic proximity Read ↗

The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolenseSemantic proximity Read ↗

Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.