Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?

doi:10.1016/j.gene.2014.09.047

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Article

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?

Gene - 1 Feb 2015

Günzl Arthur, Kirkham Justin K, Nguyen Tu N, Badjatia Nitika, Park Sung Hee

Abstract excerpt

Trypanosoma brucei is a vector borne, lethal protistan parasite of humans and livestock in sub-Saharan Africa. Antigenic variation of its cell surface coat enables the parasite to evade adaptive immune responses and to live freely in the blood of its mammalian hosts. The coat consists of ten million copies of variant surface glycoprotein (VSG) that is expressed from a single VSG gene, drawn from a large...

Topics

Alleles
Allelic Imbalance
Gene Expression Regulation
Gene Silencing
Genes, Protozoan
Promoter Regions, Genetic
RNA Polymerase I
Telomere
Transcription Initiation Site
Trypanosoma brucei brucei
Variant Surface Glycoproteins, Trypanosoma

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Identifiers

PMID: 25261847
DOI: 10.1016/j.gene.2014.09.047
PMCID: PMC4272636

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