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Article

TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.

The Journal of cell biology - 5 Jul 2021

Meitinger Franz, Kong Dong, Ohta Midori, Desai Arshad, Oegema Karen, Loncarek Jadranka

Abstract excerpt

Centrosomes are composed of a centriolar core surrounded by pericentriolar material that nucleates microtubules. The ubiquitin ligase TRIM37 localizes to centrosomes, but its centrosomal roles are not yet defined. We show that TRIM37 does not control centriole duplication, structure, or the ability of centrioles to form cilia but instead prevents assembly of an ectopic centrobin-scaffolded structured condensate...

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Share to Centrioles
Share to Centrosome
Share to Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Mitosis

Share to Spindle Apparatus

Share to Tripartite Motif Proteins

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Source

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Identifiers

PMID: 33983387
DOI: 10.1083/jcb.202010180
PMCID: PMC8127006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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