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CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells

30 Nov 2023

Abstract excerpt

Cyclin-dependent Kinase 2 (CDK2) inhibition prevents supernumerary centrosome clustering. This causes multipolarity, anaphase catastrophe and apoptotic death of aneuploid cancers. This study elucidated how CDK2 antagonism affected centrosome stoichiometry. Focused ion beam scanning electron microscopy (FIB-SEM) and immunofluorescent imaging were used. Studies interrogated multipolar mitosis after pharmacologic or...

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PMID: 38031910
DOI: 10.1080/15384047.2023.2279241

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