Article
53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.
The Journal of cell biology - 18 Jul 2016
Meitinger Franz, Anzola John V, Kaulich Manuel, Richardson Amelia, Stender Joshua D, Benner Christopher, Glass Christopher K, Dowdy Steven F, Desai Arshad, Shiau Andrew K, Oegema Karen
Abstract excerpt
In normal human cells, centrosome loss induced by centrinone-a specific centrosome duplication inhibitor-leads to irreversible, p53-dependent G1 arrest by an unknown mechanism. A genome-wide CRISPR/Cas9 screen for centrinone resistance identified genes encoding the p53-binding protein 53BP1, the deubiquitinase USP28, and the ubiquitin ligase TRIM37. Deletion of TP53BP1, USP28, or TRIM37 prevented p53 elevation in...
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