Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anaphase catastrophe is a target for cancer therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2011

Galimberti Fabrizio, Thompson Sarah L, Ravi Saranya, Compton Duane A, Dmitrovsky Ethan

Abstract excerpt

Neoplastic cells are genetically unstable. Strategies that target pathways affecting genome instability can be exploited to disrupt tumor cell growth, potentially with limited consequences to normal cells. Chromosomal instability (CIN) is one type of genome instability characterized by mitotic defects that increase the rate of chromosome mis-segregation. CIN is frequently caused by extra centrosomes that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Centrosome

Share to Chromosomal Instability

Share to Cyclin-Dependent Kinase 2

Share to Medical Oncology

Share to Mitosis

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21288923
DOI: 10.1158/1078-0432.CCR-10-1178
PMCID: PMC3061280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anaphase catastrophe is a target for cancer therapy.PMID 21288923Read ↗

Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity Read ↗

New Cell Cycle Inhibitors Target Aneuploidy in Cancer TherapySemantic proximity Read ↗

Mitotic slippage: an old tale with a new twistSemantic proximity Read ↗

Centrosome amplification, chromosome instability and cancer development.Semantic proximity Read ↗

Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast CancerSemantic proximity Read ↗

Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2Semantic proximity Read ↗

Human Cancer Cells Commonly Acquire DNA Damage during Mitotic ArrestSemantic proximity Read ↗

CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cellsSemantic proximity Read ↗

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.Semantic proximity Read ↗

FOXM1 is critical for the fitness recovery of chromosomally unstable cellsSemantic proximity Read ↗

Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindlesSemantic proximity Read ↗

Targeting the Mitotic Catastrophe Signaling Pathway in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.