Article

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

2022-07-22

Abstract excerpt

Hepatic fibrosis is the primary determinant of mortality in nonalcoholic steatohepatitis (NASH) patients. Antagonism of transforming growth factor β (TGFβ), a master profibrogenic cytokine, is a promising therapeutic target that has not yet been translated into an effective therapy, due in part to the lack of animal models resembling the human phenotype of NASH. Here we have identified that soluble secreted folate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0839d51-4591-522d-ae13-13aa18ceb020
DOI: 10.1101/2022.07.21.500829

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cellsDOI 10.1101/2022.07.21.500829Read

Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitisSemantic proximity Read

Semaphorin 3C exacerbates liver fibrosisSemantic proximity Read

Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical TranslationSemantic proximity Read

Time-course RNA sequencing reveals high similarity in mRNAome between hepatic stellate cells activated by agalactosyl IgG and TGF-β1Semantic proximity Read

Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal MyofibroblastsSemantic proximity Read

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.Semantic proximity Read

MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes.Semantic proximity Read

Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Loss of SARA in Hepatic Stellate Cells Exacerbates Experimental Liver FibrosisSemantic proximity Read

Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regenerationSemantic proximity Read

Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in MiceSemantic proximity Read

Homocysteine Metabolic Dysregulation Drives Oral Submucous Fibrosis and is Rescued by 5-Methyltetrahydrofolate InterventionSemantic proximity Read