Article

Semaphorin 3C exacerbates liver fibrosis

2021-07-29

Abstract excerpt

<h4>Background & Aims</h4> Chronic liver disease is a growing epidemic leading to fibrosis and cirrhosis. TGF-β is the pivotal pro-fibrogenic cytokine which activates hepatic stellate cells (HSC), yet, other molecules can substantially modulate TGF-β signaling in the course of liver fibrosis. Expression of the axon guidance molecules Semaphorins (SEMAs), which signal through Plexins and Neuropilins (NRPs), have b...

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Literature Corpus work: 1546ede3-fb04-5cc3-b245-457ee16915cb
DOI: 10.1101/2021.07.29.454292

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