Article

Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

2024-01-05

Abstract excerpt

Gremlin-1 has been implicated in liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) via inhibition of bone-morphogenetic protein (BMP) signalling and has thereby been identified as a potential therapeutic target. Using rat in vivo and human in vitro and ex vivo model systems of MASH fibrosis, we show that neutralisation of Gremlin-1 activity with monoclonal therapeutic antibodies does not...

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Literature Corpus work: 95d7bb96-78c1-5c4c-b41f-cb969a7d308f
DOI: 10.1101/2024.01.03.574043

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