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Article

Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice

1 Jan 2023

Abstract excerpt

Background & Aims Nonalcoholic steatohepatitis (NASH) is a complex disease involving both genetic and environmental factors in its onset and progression. We analyzed NASH phenotypes in a genetically diverse cohort of mice, the Hybrid Mouse Diversity Panel, to identify genes contributing to disease susceptibility. Methods A "systems genetics" approach, involving integration of genetic, transcriptomic, and...

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Share to Growth Hormone and Insulin-like Growth Factors
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Identifiers

PMID: 37611662
DOI: 10.1016/j.jcmgh.2023.08.007

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