Article
Size-scaling promotes senescence-like changes in proteome and organelle content
2021-08-05
Abstract excerpt
Senescent cells typically have an enlarged cell size but the reason for this has not been fully elucidated. As abnormal cell size may alter protein concentrations and cellular functionality, we used proteomic data from 59 unperturbed human cell lines to systematically characterize cell-size dependent changes in intracellular protein concentrations and organelle content. Increase in cell size leads to ubiquitous tr...
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Identifiers and source
- Literature Corpus work
- a07b507e-ce73-513f-9988-ee2368c5e909
- DOI
- 10.1101/2021.08.05.455193