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Bridging Gene Expression and Morphology: A Cell Size Score and Its Applications Across Multiple Diseases and Physiological Contexts

2026-07-02

Abstract excerpt

Cell size is a critical morphological parameter determining cellular functional homeostasis, yet existing large-scale transcriptomic databases lack direct cell size measurement data. By integrating high-resolution immunofluorescence images with transcriptomics, we identified 457 genes significantly correlated with cell area. Based on these findings, we developed an algorithm, Cell Size Score (CSS), to predict cell...

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Literature Corpus work
1b86104a-2701-541d-8fb4-504e68268e27
DOI
10.64898/2026.06.28.733694
Open publication

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