Article

Single-Cell Spatial Proteomics Uncovers Molecular Interconnectivity among Hallmarks of Aging

2026-02-28

Abstract excerpt

<h4>Summary</h4> Aging is accompanied by conserved hallmarks including genomic instability, epigenetic alterations, loss of proteostasis, and mitochondrial dysfunction, but how these processes emerge and become mechanistically linked remains unclear. Here we leverage a proteome-wide, single-cell, subcellular atlas of protein expression, localization, and aggregation across yeast replicative aging to map hallmark-...

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Literature Corpus work: fcd5f83f-1a8e-5969-95c6-fbd28074e83b
DOI: 10.64898/2026.02.26.708335

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