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The lysosomal proteome of senescent cells contributes to the senescence secretome

10 Sept 2022

Abstract excerpt

Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age-related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity. Here, we report that two main autophagic pathways macroautophagy (MA) and chaperone-mediated autophagy (CMA) are constitutively upregulated in senescent cells. Proteomic analyses of the subpopulations...

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PMID: 36087066
DOI: 10.1111/acel.13707

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