Article

Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan

2026-02-16

Abstract excerpt

<h4>Summary</h4> The molecular and cellular basis of aging and its associated functional decline remains poorly understood. Even free-living microorganisms age and, in yeast, replicative aging shares key hallmarks with human cellular senescence, including progressive cell enlargement. Recent work has shown that chemical and genetic manipulations that increase cell size promote the onset of senescence in both yeas...

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Literature Corpus work: 24cfa265-6a2d-51b0-b94b-1462d3fee082
DOI: 10.64898/2026.02.15.706013

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