Article

Lysosomal Profiling with LysoTracker for Quantitative Assessment of Cellular Senescence in Human Fibroblasts

2026-04-17

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a stable cell-cycle arrest state associated with characteristic phenotypes, including enlarged cell morphology, altered secretory signaling, and pronounced lysosomal remodeling. Senescent cells commonly accumulate increased numbers of enlarged lysosomes with changes in acidity and degradative capacity, creating an opportunity for simple live-cell readouts of senescence-lin...

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Literature Corpus work: a33b5fb0-1903-5b43-81d9-f7d94a450816
DOI: 10.64898/2026.04.16.719007

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