Article

Notch Inhibition Enhances Morphological Reprogramming of microRNA-Induced Human Neurons

2024-01-12

Abstract excerpt

Although the importance of Notch signaling in brain development is well-known, its specific contribution to cellular reprogramming remains less defined. Here, we use microRNA-induced neurons that are directly reprogrammed from human fibroblasts to determine how Notch signaling contributes to neuronal identity. We found that inhibiting Notch signaling led to an increase in neurite extension, while activating Notch...

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Literature Corpus work: a07a4a6d-9a90-501d-af9a-9a28a3a19d27
DOI: 10.1101/2024.01.12.575384

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